Lots of people recommended Papers to me (since I have an old Mac in my office), but I find I am using the Mac less and less (since my lab instrumentation is all Windows based, and I like to look at the raw data occasionally). It looks like I will probably start hooking my PC subnotebook up to my big monitor. So I want at least a cross-platform solution.
I decided to try out Mendeley, and I like it so far. I let it grab my paper data out of the pdf files, which took a little while. Once set up, I found that while most of the details it grabbed were correct, I do need to look at entries before using them. Rather than wasting time fixing stuff, I am fixing entries as I use them. There is a tool to look papers up by title in Google Scholar if the data grabbed from the pdf is incorrect, and that is pretty handy.
I am not used to using anything but Adobe to read pdfs, but the ability to add notes to my papers (and highlight text) seems like it could be pretty handy. It is also possible to share annotated papers, which I may eventually do with my group. I signed up for the Web account, but I don't know if I will use it. For now, I just want something that can insert references properly into my manuscripts (I am not a LaTeX person) and search through my library of pdfs.
I'll post a more extensive review after I use Mendeley for the manuscript I started yesterday. Anyone else have paper/reference management software suggestions?